国内外有关针刺、电刺激脑及吗啡镇痛的研究都指出第Ⅲ脑室尾端侧壁灰质及导水管周围灰质(PAG)是镇痛的有效部位。关于 PAG 已有深入的研究

而第Ⅲ脑室尾端侧壁灰质方面报道较少

迄今未见电生理研究的资料。本工作直接观察电针过程中第Ⅲ脑室尾端侧壁灰质(下丘脑室周核

hpv)神经元活动的变化

与其紧邻下丘脑后核(hp)的反应相比较

并初步分析其机制.The influences of electro-acupuncture(EA)on spontaneous unit dis- charges of nucleus periventricularis hypothalami(hpv)and the adjacent nucleus posterior hypothalami(hp)were observed.The discharge rate of the majority of hpv neurons was increased during EA and decreased imme- diately after EA

while this predominating response did not occur in hp

thus indicating that the response of the hpv neurons was specific.This study also showed the diphasic effect(excitation followed by inhibition) of EA on hpv neurons could be completely reversed by naloxone(0.1mg/kg i.v.).Morphine(1mg/kg i.v.)had a similar diphasic action on hpv neurons. These results indicated that the effect of EA might be conducted through releasing endogenous opiate-like substance which acted on the opiate re- ceptors in hpv neurons.