皮质醇系肾上腺皮质分泌的主要激素之一

它受下丘脑-垂体的控制

对机体生理功能的调节起重要的作用。有报导指出

利血平可耗竭去甲肾上腺素(NE)神经递质

从而解除对腺垂体的抑制作用

使促肾上腺皮质激素(ACTH)分泌增加

导致血浆皮质醇浓度升高。亦有人证实

针刺可使皮质醇分泌增加

同时多数的报导也指出针刺使脑内NE含量减少。因而推想

在利血平化的基础上给予针刺

应该比单独使某一种时所引起的效果大一些。本文针对这个问题

分别测定针刺和利血平对血浆In order to investigate the mechanism of acupuncture on the secretion of cortisol

we used the IRA method in the determination of cortisol. Fifty rabbits were divided into five groups. (1) Electro-acupuncture of Zusanli point for fifteen minutes (EAZ) group. Apparatus Type G 6805 was used(wave form continuous

1 Hz; Output intensity at scale 1.5) (2) Electro-acupuncture of control point but not of Zusanli point. (3) Reserpine group : i.v.reserpine 2 mg/kg. (4)Reserpine+FEAZ Group: After the injection of reserpine for one hour

the electro-acupuncture of Zusanli point was carried out. After two hours

the blood samples were taken. (5) Control group: Without any treatment. The results were as follows 1. From 1-12 hours after the combination of electro-stimulation on Zu- sanli point and i.v.reserpine

the serum cortisol level was increased. The reaction was specific since no effects were found when the control points were stimulated. 2.After exhaustion of the mediators of the adrenergic nerves by reser- pine

the cortisol level was significantly increase. It was found that the peak level of rising cortisol was earlier than that of EAZ Groups. 3.Combined effect of the EAZ+i.v. reserpine was greater than that of either electrostimulation of Zusanli point or i.v.reserpine alone.The is su- ggested that the effect of electrostimulation on the point of Zusanli could only be partially explained by the effect of inhibition of control adrenergic system. The other possible mechanism for the increase of ACTH secretion is to be further investigated