针刺“人中”穴具有升高血压的作用已被大量临床和实验工作证明。近年来对于中枢介质参与血压调节也逐渐引起更多的注意。为了探讨针刺升高血压的中枢机制

乃采用不同药物作侧脑室内注射

观察对电针升压作用的影响。方法采用220～280克大鼠

性别不拘

以每公斤1.2克的乌拉坦皮下注射

在麻醉下做颈动脉插管和双侧颅骨钻孔(距前囱2毫米

距中缝线2毫米)备测量血压和侧脑室注射用。使用SJ—41型多导生理记录仪描记血压和心率。首先描记基础血压和心率

It is well known that the blood pressure may be increased by electro-acu- puncture on certain point

but the relationship between central neurotran- smitter and the pressor effect of acupuncture has been rarely studied. In this article the roles played by the central cholinergic activity in the pressor response of electroacupuncture(EA) are reported. The pressor effect of EA on "Renzhong" point was demonstrated in anesthetized rats. This pressor effect was reenforced by ICV injection of 2.5～5μg neostigmine but depressed by previous ICV administration of HC-3 and atropine. Either naloxone or pentolamine injection exerts some inhibi- tory effect on the pressor response of EA. Therefore the pressor effect of EA is intimately related with central cholinergic activity

Both opiate re- ceptor and α-adrenergic receptor are also invovved in the pressor response of EA. The reenforcing effect of neostigmine on pressor response of EA can be antagonized by naloxone but not by pentolamine. This result suggests that some functional linkage exists between the central vasomotor control of cholinergic system and the opiate like substance of the brain