为了阐明针刺治疗冠心病过程中冠脉侧支循环功能

在戊巴比妥钠30毫克/公斤麻醉下

将颈动脉血液通过三通插管供给冠脉左前降支(LAD)

关闭三通以阻断冠脉血运造成心肌梗塞

而后测定冠脉回返血流量(RF)和梗塞区冠脉压

并测量左室内压和股动脉压等指标

观察针刺双侧内关穴的效应

针刺组和不给针刺对照组各用犬15只

所得结果如下: 当梗塞15分钟心率、动脉压、冠脉压、跨越侧支血管网压力梯度、心内膜下区灌注压和心肌梗塞区及缺血区血管阻力和返回血流量仅有轻度变化

但左室舒张期终末For expounding the function of coronary collateral circulation during treating coronary heart diseases with acupuncture

the dogs were anaest- hetized with sodium pentobarbital (30Mg/Kg)

the left anterior descen- ding branch of coronary artery (LAD) was supplied with blood from ca- rotid

through a three-way tube. When the three-way tube was turned off the myocardial infarction was occured by the blocking blood flow. The coronary return flow (RF)

coronary pressure in the infarcted area

left ventricular pressure

femoral artery pressure were measured

and the ef- fects of acupuncture applied on Neiguan point and control 15 animls for each group were observed. The results are as follows: When the myocardium had been infarcted for 15 minutes

heart rate

artery pressure

coronary artery pressure

pressure difference of the col- lateral vessels

perfusion pressue in subendocardium and vessel resistance and RF in infarcted and ischemic myocardial areas were only altered

but LVEDP was increased. After the prolonged period of myocardial infarction

the most of indices mentionead above in control group were decreased

but vessel resistance and LVEDP in infarcted area were increased. All of them demonstrated that the myocardial infarction was serious

the number of closed anasto- motic branches of coronary collateral vessel was increased

so that the RF was decreased. Comparing with control group

artery pressure

coronary artery press- ure difference and perfusion pressure of the acupuncture group were inc- reased. However

the vessel resistance and LVEDP in infarcted and ische- mic areas were decreased. It resulted in the increasing of RF. It was sug- gested that the collateral circulation reserve in myocardial ischemic area could be mobilzed and the number of opened coronary vessel and the blood supply of ischemic area could be improved and increased by acupuncture.