祖国医学很早就提到惊恐或愤怒等情绪引起心律失常

目前临床也对情绪激动或应激反应在心律失常发病中作用日益重视

我们以往工作表明

在家兔可建立针刺治疗实验性心律失常的模型

并对其作用机理作初步探讨。本文进一步观察延髓腹侧区在针刺抑制实验性心律失常中的作用。家兔58只

用乌拉坦(700毫克/公斤)和氯醛糖(35毫克/公斤)静脉麻醉

三碘季铵酚制动

在人工呼吸下进行实验。用电刺激下丘脑近中线区的方法诱发室性期前收Experiments were carried out on 58 rabbits anesthetized with chloralose and urethane. The animals were immobilized with gallamin triethiodide and maintained by artifical ventilation. Microinjection of morphine (5 g in 0.5-1μl) into the ventral medullary areas bilaterally decreased the num- ber of hypothalamic stimulation-induced ventricular extrasystoles (HVE). Inhibition of HVE by electrical stimulation of caudal raphe nuclei or by microinjection of L-sodium glutamate (0.5mM

0.5-1μl) intc the same area were diminished by microinjection of naloxone into the ventral medullary area bilaterally. Inhibition of HVE by electrical stimulation of deep ocroneal nerve (DPN) was less obvious or even abolished by microinjection of naloxone (2μg 0.5-1μl) into the ventral medullary areas bilaterally. These results suggest that the inhibitory efedt of DPN stimulation on HVE is mediated by activation of opiate receptors in the ventral medul- lary areas via caudal raphe nuclei.