Investigation on the mechanism underlying the formation of the propagated sensation along channels(PSC)is one of the important problems in the rese- arch of channels and collaterals.In this respect

there are two suppositions at present

namely

“spreading of excitation in CNS(centnal nervous system)” and “activation in sequence in periphery.”Both the two were evidenced by some experiment results.Faced with such a case

how can we interpret its mechanism more satisfactorily?Based on the data accumulated in PSC research and the fundamental facts in biology

particularly

tthe fact that the activi- ties of the peripheral structures and its afferent inputs play a decisive role in keeping the normal function and organization of CNS

which have been repea- tedly confirmed for many years

we advance the present hypothesis.Accordi- ng to this hypothesis

“peripheral”and“Central mechanism”are operated as a whole.There is a substantial process proceeding along the channels in peri- phery and also a corresponding functional organization in CNS.Although the central mechanism may be brought into play in some cases

the peripheral substantial process is the determinant in the integration of the“periphery”and CNS. From the neurophysiological point of view

tha activities of the periphe- ral structure must leave some trace

slight or profound in CNS.As a steady biological phenomenon

PSC must be formed in the course of phylogeny

thus. it is very possible to leave a steady trace or functional connections(or “organizat ion of channels”)in CNS

acting as the central mechanism in the formation of PSC.However

these particular functional connections can never be formed without foundation

it must be subordinate to the principle of evolu- tion.First of all

it depends on the peripherals tructre and its activities.In other words

the functional organization in CNS is just the reflection of the priepheral structure and its activities

but not in reverse.Therefore

if there are some particular functional connections(or“organization of channels”)in CNS

then there must be certain substantial process proceeding along the channel as well.The“central organization of channels”is merely a reflection or projec- ction of the“aperipheral substantial process”.It is absolutely impossible to make appearance in CNS without the peripheral substantial process along the hannel.In other words

in the integration of“periphery”and CNS

the det- erminant is the peripheral substantial process along the channel.This hypo- thesisis not only based on sufficient theoritical consideration but also supported by not a few experimental results.We believe that it would be evidenced by more of the facts and give a clear interpretation of the mechanism of the formation of PSC.