以 Freund 氏完全佐剂形成的大鼠实验性关节炎属于Ⅲ型变态反应性疾病

炎症肢体红肿、发热、运动障碍

局部痛阈明显降低

症状持续约一个月左右逐渐消退。我们使用针刺两侧环跳穴可以提高全身痛阈

对炎症局部痛阈的提高尤为显著。但针刺提高痛阈的强度不高

镇痛持续的时间不长

所以还不能满足临床上的要求。鉴于针刺可以增加体内脑啡肽的释放

因此针刺合并使用阿片受体激动剂芬太尼与多巴胺受体拮抗剂氟哌啶可以较大地增强针刺的镇痛效果。因此本实验在此基础上进一步研究针药合并对于炎症局部慢性痛的镇痛作用

为临床治疗寻找较好的途径。方法动物模型

SD 大鼠

体重约150～200克

雌雄各半

分性别、组别饲养

水食自Our previous study demonstrated that acupuncture increased pain threshold of the body

especially in the inflammatory area.Because acupuncture can promote the release of enkephalin in the brain

it is possible that analgesic effect of acupuncture could be fdrther strengthened by administration of fentanylan opioid receptor's agonist and droperidol-dopamine receptor's agonist at same time. In present study arthritic rats induced by freund's complete adjuvent were divided into two groups.All of them received electro-acupuncture on bilateral“Hung-Tiao” points for 15 minutes.The first group animals were also given with common dose of fenanyl 10μg/kg and droperidol 0.5mg/kg by intraperitoneal injection.Pain threshold increased very soon after needling and drugs given.The analgesic effect lasted as long as 180 minutes.There is a statistical siginficant difference between this common dose group and acupuncture control group which only kept analgesic effect 90 minutes

P<0.01.When only 1/5 dose of these druge with acupuncture was applied to arthritic rats

not only the pain threshold reached to 180+30% (P<0.01)

but also the ana- lgesic effect persisted as long as 120 minutes (P<0.01).The results from mentiond above suggested that if a small dose of drug is no effect in usual treatment

it could still play a role and reduce the pharmacological side effect by way of combining acupuncture application.