临床针麻手术有配合使用氯胺酮提高其效果

但也有持相反的意见。在我们以往的一些工作中主要是观察大鼠在清醒状态下的行为反应

因此一些必要的手术是在氯胺酮麻醉下完成的。由于氯胺酮的作用时间较短

动物可很快恢复

便于进行实验

但是否会影响到针刺镇痛作用的研究

这是个值得考虑的问题。有报导氯胺酮有拮抗There were different opinions about whether ketamine has an antagonisticeffect on electroacupuncture (EA) analgesia. The aim of this paper was to inve-stigate the effect of ketamine on EA. The rats were divided into three groups: 4mg/kg

20mg/kg of ketamine in doses

and normal saline groups. Ketamine was injected peritoneally in dosage of 4mg/kg and 20mg/kg respectively. Tail flick latency (TFL) and vocalization threshold (VT) were taken as the indices of pain responses. Changqiang andYaoshu acupoints were selected for electroacupuncture. It was observed that the analgesia effects of EA were attenuated after in-jection of ketamine either in 4mg/kg group or 20mg/kg group. The results indicate that 4mg/kg or 20mg/kg ketamine in doses has anantagonistic effect on EA analgesia

suggesting that attention should be paid to the dosage when ketamine is used for EA analgesia.