EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS
Wang Youjing Wang Shuangkun. EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS[J]. Acupuncture research, 1989, (3): 348-351.
Wang Youjing Wang Shuangkun. EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS[J]. Acupuncture research, 1989, (3): 348-351.DOI:
大鼠腹腔注射纳洛酮对电针镇痛效应及其脑内儿茶酚胺含量变化的影响
摘要
中枢儿茶酚胺(CA)主要有去甲肾上腺素(NA)和(DA)。我们曾观察到电针后大鼠脑内 NA 和 DA 含量发生显著变化
Naloxone and Naloxone plus EA.The contents of noradrenaline(NA)and dopamine (DA) in brain stem
diencephalon and telencephalon were deter- mined by fluorespectrometry.It was found that the pain threshold increased and the NA content in the telencephalon decreased and the DA level in the brain stem increased markedly after EA.Naloxone injection partially decrea- sed the analgesic effect of EA and abolished the EA-induced elevation of DA in the brain stem and attenuated the NA level in the diencephalon after EA. These results suggest that morphine receptor may play an important role in EA analgesia and this may be patially carried out through the brain cate-cholamine system.