很早就有人发现

外周神经逆向刺激可引起外周神经血管的扩张和血浆渗出

用染色剂注入血管与血浆蛋白结合后随血浆渗出可在被刺激的神经支配区域皮肤上The neurogenic inflammation caused by antidromic stimulation of the saphenous nerve was taken as an index of peripheral release of substance Po Electroacupuncture could reduce the plasma extrava

a

tion from the neurogenic infilaruination by 69.7%

but electroacupuncture per se did not cause obvious plasma extravasation. In rats pretreated with capsaicin the plasma extravasation could be markedly reduced

in consistent with the reduction of substance P-like immunoreactivity in dorsal horn. It is referred that electroacuPuneture might block the conveying the signals induced by nerve stimulation along the C-fibers and the axo-axonal reflex

leading to the reduction of peripheral releease of substance P. Besides the mediation by different central structures

acupuncture might have direct effects on regulating peripherally the release of some inflammatory and painful mediators.