5.7-双羟色胺对关节痛大鼠电针镇痛及中枢P物质含量的影响

崔仁麟; 赵飞跃; 马春红; 田宇瑛; 蔡红; 朱丽霞

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5.7-双羟色胺对关节痛大鼠电针镇痛及中枢P物质含量的影响

更新时间：2023-08-11

- 5.7-双羟色胺对关节痛大鼠电针镇痛及中枢P物质含量的影响
- INFLUENCE OF 5.7-DIHYDROXYTRYPTAMINE ON ELECTRO-ACUPUNCTURE ANALGESIA AND SUBSTANCE P LEVEL IN CENTRAL NERVOUS SYSTEM OF THE ARTHRALGIC RATS
- 针刺研究 1992年第3期页码：183-185
- 作者机构：
  
  中国中医研究院针灸研究所
- 作者简介：
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- 纸质出版日期：1992
- 稿件说明：
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崔仁麟, 赵飞跃, 马春红, 等. 5.7-双羟色胺对关节痛大鼠电针镇痛及中枢P物质含量的影响[J]. 针刺研究, 1992,(3):183-185.

Cui Renlin, Zhao Feiyue, Ma Chunhong, et al. INFLUENCE OF 5.7-DIHYDROXYTRYPTAMINE ON ELECTRO-ACUPUNCTURE ANALGESIA AND SUBSTANCE P LEVEL IN CENTRAL NERVOUS SYSTEM OF THE ARTHRALGIC RATS[J]. Acupuncture research, 1992, (3): 183-185.
崔仁麟, 赵飞跃, 马春红, 等. 5.7-双羟色胺对关节痛大鼠电针镇痛及中枢P物质含量的影响[J]. 针刺研究, 1992,(3):183-185. DOI：

Cui Renlin, Zhao Feiyue, Ma Chunhong, et al. INFLUENCE OF 5.7-DIHYDROXYTRYPTAMINE ON ELECTRO-ACUPUNCTURE ANALGESIA AND SUBSTANCE P LEVEL IN CENTRAL NERVOUS SYSTEM OF THE ARTHRALGIC RATS[J]. Acupuncture research, 1992, (3): 183-185. DOI：

摘要

以前的实验证明

电针镇痛同时提高脑干5-羟色胺(5-HT)水平可能是通过5-HT能下行抑制起作用。大鼠给予对氯苯丙氨酸(PCPA)

耗竭脑内5-HT可消除电针镇The relation between clectroacupuncture (EA)analgesia (A)and substance P (SP)level in the brain stem(BS) and lumbar sp(?)nal cord (LSC) of arthralgic rats was investigated. The rats were divided into three groups:1)5.7-dihydroxytryptamine(5·7-DHT)+EA

2)vehicle(V)+EA

and 3)5·7-DHT. All the animals were induced arthralgesia by injecting Freund's adjuvant 7 days after cisterna injection of 5·7-DHT or vehicle. The SP level in the BS and LSC was determined by RIA. The results indicated that in V+EA group the EA could prolong tail flick latency by 39.6%

but in other two groups did not. The SP level in LSC of V+EA group (179.1±11.5pmol/g) was higher than that in the 5·7-DHT+EA (135.9+9.3pmol/g)and 5·7-DHT (125.8±10.0 pmol/g) groups. It suggested that both EA and arthralgia could activate the descending 5-HTergic inhibitory system to inhibit the release of SP in LSC

When the 5-HTergic system was destroyedby 5·7-DHT

the EAA was attenuated

and the SP level in LSC was lowered due to its release was decreased by EA and arthralgia.

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