肾上腺素受体具有广泛的临床意义

近年发展迅速。脑内去甲肾上腺素神经递质

主要通过α受体对抗针刺镇痛。α受体在脑内有α_1和α_2两种

它们对电针镇痛的影响如何?本文研究特异作用于α_2肾上The role of central nor-epinephrine(NE)in electroacupnture(EA) analyesia is a controversial question

it is probably due to the complication of adrenergic receptors. The present results show: (l)Clonidine 30ug/2ml/kg ip had no significant effect on the pain threshold

but decreased the analgesic effect of EA. Clonidine 1.5 and 3μg were injected into the lateral cerebral ventricles. After 45 minutes

the analgesic effect of EA was lowered as compared with the saline controls respectively

(2)Yohimbine had no significant effect on the basal pain threshold

but(icv Yoh 50μg)clcvatcd the analgesic effect of EA. (3)21-adrcnoceptor agonist methoxamine decreased the analgesic effect of EA

(4)Another 21-adrenoceptor antagonist prazosin(icv 16μg)enhanced the analgesic effect of EA

These results suggest that an activation of α_1- or α_2-adrenoceptors would decrease the analgesic effect of EA.