不同频率对关节炎大鼠痛反应及中枢γ—氨基丁酸和谷氨酸含量的影响

曹蔚鸿; 邓颖; 董晓彤; 王友京; 陆卓珊

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不同频率对关节炎大鼠痛反应及中枢γ—氨基丁酸和谷氨酸含量的影响

更新时间：2023-08-11

- 不同频率对关节炎大鼠痛反应及中枢γ—氨基丁酸和谷氨酸含量的影响
- EFFECTS OF ELECTROACUPUNCTURE AT DIFFERENT FREQUENCIES ON THE NOCICEPTIVE RESPONSE AND CENTRAL CONTENTS OF GABA AND GLUTAMIC ACID IN ARTHRITIC RATS
- 针刺研究 1993年第1期页码：48-52
- 作者机构：
  
  中国中医研究院针灸研究所
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- 纸质出版日期：1993
- 稿件说明：
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曹蔚鸿, 邓颖, 董晓彤, 等. 不同频率对关节炎大鼠痛反应及中枢γ—氨基丁酸和谷氨酸含量的影响[J]. 针刺研究, 1993,(1):48-52.

Cao Weihong Deng Ying Dong Xiaotong Wang YouJing Lu Zhuoshan. EFFECTS OF ELECTROACUPUNCTURE AT DIFFERENT FREQUENCIES ON THE NOCICEPTIVE RESPONSE AND CENTRAL CONTENTS OF GABA AND GLUTAMIC ACID IN ARTHRITIC RATS[J]. Acupuncture research, 1993, (1): 48-52.
曹蔚鸿, 邓颖, 董晓彤, 等. 不同频率对关节炎大鼠痛反应及中枢γ—氨基丁酸和谷氨酸含量的影响[J]. 针刺研究, 1993,(1):48-52. DOI：

Cao Weihong Deng Ying Dong Xiaotong Wang YouJing Lu Zhuoshan. EFFECTS OF ELECTROACUPUNCTURE AT DIFFERENT FREQUENCIES ON THE NOCICEPTIVE RESPONSE AND CENTRAL CONTENTS OF GABA AND GLUTAMIC ACID IN ARTHRITIC RATS[J]. Acupuncture research, 1993, (1): 48-52. DOI：

摘要

电针在急性关节炎动物模型上有镇痛作用

但不同电针参数的研究未见报道。本实验用100赫芝和15赫芝两种频率电针关节炎大鼠阳陵泉穴

可见低频电针镇痛效应优于高频电针;低频电针组脊髓谷氨酸含量低于高频电针组

γ-氨基丁酸含量在两组间无明显著差别。结果提示脊髓谷氨酸可能与不同频率电针的镇痛效应有密切关系。

Abstract

It has been demonstrated that electroacupuncture (EA) produces analgesiain acute arthritic animal models

while the differential analgesic effects at dif-ferent EA parameters remains to be discovered.In the present experiment

theeffects of EA at 100 Hz and 15 Hz on bilateral Yanglingpuan acupoints of thearthritic rats was studied.The results showed:1) 15Hz EA was more effectivethan 10Hz EA for analgesia;2) spinal glutamic acid content of the 15-Hz EAgroup was significantly lower than that of the 100-Hz EA group

and 3) nosignificant difference in GABA contents between the two groups was found.The results suggest that spinal glutamic acid may be involved in the differentanalgesic effects of EA at different frequencies in arthritic rats.

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