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1. 上海医科大学神经生物学教研室,上海,200032
2. 上海医科大学医学神经生物学国家重点实验室,上海,200032
纸质出版日期:1994
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应赛霞, 程介士. 电针对沙鼠脑缺血及再灌注时脑电活动的影响[J]. 针刺研究, 1994,(1):29-32.
Effects of Electro-acupuncture on EEG During Transient Global Ischemia and Reperfusion in Gerbils[J]. Acupuncture research, 1994, (1): 29-32.
在急性沙鼠全脑缺血和再灌注模型上,应用计算机统计脑电总功率的方法,研究了针刺对脑缺血及再灌注各期脑电总功率的影响。发现缺血10min,脑电幅度受到严重抑制,总功率大大下降,再灌注后总功率难以恢复,对照组在120min恢复达最高水平时仅为缺血前的27.39±11.31%。电针组动物缺血10min再灌注后,脑电的恢复明显比对照组快,120min时恢复至缺血前的71.45±16.46%(P<0.01),240min时继续恢复至缺血前的75.27±18.43%。实验结果表明,电针能减轻脑缺血时脑电活动的抑制和促进再灌注后脑电活动的恢复。
In the model of gerbil of acute global ischemia and reperfusion
we studied the effects of electroacupuncture (EA) on total power of EEG at different periods of global ischemia and reperfusion. The "Fengfu" (GV 16) and "Jinsuo" (GV 8) points were stimulated by electrical pulse with frequency 7 Hz and intensity of 5-6 mA for 30 min. Recording was made before ischemia and 0 min
15min
30min
60min
120 min and 240 min after reperfusion respetively. The results were as follows:1. In hte control group
after 10 min of ischemia
the amplitude of EEG was severely inhibited
even became flatten
and the total power of EEG was significantly decreased to 1. 41 + 1. 29% .After reperfusion
the recovery of total power was very slow. The peak level of recovery occured at 120 min following reperfusion was 27. 39+ 11. 31%.2. In comparison with the control group
the EA remarkably improved the recovery of EEG after ischemia and reperfusion. The recovery of total power was 71. 45 + 16. 46% (P<0. 01)
and 75. 27+ 18. 43 % (P<0. 01) at 120 min and 240 min after reperfusion respectively.These results strongly indicte that EA could reduce the EEG inhibition during global ischemia and improve the recovery after reperfusion
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