The experimental results displayed that the cellular immune functions of tumor-bearing mice in control group were significantly lower than that the normal control group. The cellular immune functions of those groups acccpting moxibustion treatmcnt were maintained at a relatively higher level. Among them the Guanyuan group seemed to be best in immune regulation. The data further demonstrated that an instant elevation of serum ACTH and β-EP could be caused by moxibustion. But the bariations of scrum ACTH and β-EP are not paralleled. A remarkable increase of serum β-EP was seen in Guanyuan group but not of serum ACTH. The experimental results hinted that the regulation of β-EP and ACTH was related to the immune regulation induced by moxibustion.