The changes of cAMP contents in the cerebrospinal fluid (CSF) under electroacupuncture hy-pothermia and electroacupuncture hypothermia tolerance were studied in rabbits. The results were fol-lows: (1) The body temperature rose markedly after injection of the endogenous pyrogen (EP)

and cAMP contents in CSF were increased rnarkedly at the same time. (2) ElectroacuPuncture could obvi-ously decreased the body temperature induced by EP and cAMP contents were also decreased apparent-ly. (3) Compared with the results of EP induced fever group

in eIectroacupuncture tolerance group there was no significant change in fehrile response and cAMP contents in CSF after elec-troacupuncture. The experimental results indicated that the continuous electroacupuncture could lead to the acupunclure hypothermia tolerance

and its mechanism might be related to cAMP contents in CSF.