Our previous research has shown that electro-acupuncture(EA) on "Yan.glinguan (GB 34) and "Wudaozhenchanqu" points could make the tinles of rotation of rat model of parkinson's disease (PD)reduce remarkely than that of control group. This research aimed at studying the influence df EA on tyrosine hydroxylase(TH) in dopaminerngic neurons pf substantia nigra(SN) of rnidbrain of PD rat.The result showed that some of TH-immunoreactive(iR) cells were found in normal side of SN while lesioned side of SN only contained very few of iR cells. Lots of iR cells appeared in adrenal medulla The reaction of immunqfluorescence of TH in both SN and adrenal medulla of EA group was strongel than that of control group. The result suggests that EA may regulate the activity of TH.