The aim of this work was to investigate the role of pituitory-adrenal system in the electroacupuncture modulating immune responses. We found that the multiple immune responses were declined in mice receiving cortisol ip. treatment

whereas it could be increased in mice of adrenalectomy.The IL-2

LTT contents declined by cortisol could be restored to normal levels by EA

however

the hemolytic antibody and hemoagglutinatirig antibody titer declined by cortisol were not affected by EA.In the adrenalectomized mice

except spleen LZM was declined

all the other immune parameters such as spleen PFC

IL-2

LTT

serum IgG and thymus LZM contents were increased. The EA could restore the declined spleen LZM in adrenalectomized mice to normal

but the other elevated immune parameters by adrenalectomy were not affected by EA

the immune levels were almost the same as that in the single adrenalectomy group.The above results indicate that pituitory-adrenal system may principally play an inhibitory effect in hte EA-modulating immune responses.