This work showed that electroacupuncture(EA) could enhance the ability of mhltiple irnmune re-sponses in vehicle-treated animals. To study the role of primary sensory afferent C-fibers in the effectof EA on immume response

the experiments were performed on adult mice treated by capsaicin (cap)(50mg/kg) in neonate

cap is a tool drug selectively impairing afferent C-fibers. We found that thebasal levels of multiple immune responses were changed apparently

showing that except the serumIgG decreased

all the spleen weight

thymus weight

spleen PFC

LTT

IL-2 and hemoagglutinatingantibody titer elevated obviously in cap-treated mice as compared to that in vehicle control group.After the cap-treated mice were given EA

the levels of immune responses were found to be idehti-cal with cap-treated control group. The effects of EA-regulated immune response in vehicle-treatedmice could not be observed in the cap-treated mice. The results mentioned above indicated that the ef-fects of EA-regulated immune response were related to cap-sensitive afferent C-fibers.