Thirty rats were randomly assigned to three groups

control group (10 cases)

acute cerebral is-chemia group (10 cases) and electroacupuncture (EA) group (10 cases). The bilateral common carotidarteries were occluded

which caused sharp drop of regional cerebral blood flow and led acute cerebralischemia. Contents of nitric oxide (NO) and endothalin (ET) in the cerebral cortex and boold weredetermined in normal

during occluding and after EA of Du meridian (GV 20

GV 14) point in rats.It was found that in acute cerebral ischemia

the brain contents of NO and ET increased

the plasmelevel of ET elevated and serum level of NO decreased. After EA of Du meridian point

the levels of ETand NO in the brain and blood were returned significantly to normal. It is suggested that EA at Dumeridian have protective effect on neural damage induced by brain ischemia. NO and ET are possiblyinvolved in the regulative effect of EA.