The concentrations of dynorphin(DYN)A1-13 in CSF and plasma were determined by RIA in mi-graine patients during attacks(n = 22) and controls(n = 10). The concentration of DYN A1-13 in CSF and plasma in patients with migraine without aura during attacks was significantly decreased compared with their controls (both P < 0. 01). The concentrations of CSF DYN A1-13 in the patients with severe lieadache was significantly decreased compared with those found. in the patients with moderate headache(P <0. 05). These data provide new evidence suggesting the involvement of the endogenous oplate peptides in the pathophysiology of migraine headache and suggest plasma and CSF DYN A1-13 levels could serve as a biological marker for this condition. After 30 min. of Tianrong acupoint thera-py

the concentrations of DYN A1-13 (P <0. 05 ) in plasma of migraine patients were significantly in-creased compared with before treatment. In the group of headache disappeared

the concentrations of plasma DYN Al M1-13 were significantly increased (P < 0. 01 ) after Tianrong acupoint therapy

but no significant changes were found in effective and ineffective groups. These suggest the analgesic proper-ties of the treatment may be ascribed to an involvement of the endogenous opiates system.