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广州中医药大学针灸研究所,广州,510407
纸质出版日期:1999
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赖新生, 莫飞智, 马朝笃, 等. 电针对实验性血管性痴呆大鼠学习记忆的影响[J]. 针刺研究, 1999,(3):192-197.
Influence of Electroacupuncture on Learning and Memory of Experimental Rats of Vascular Dementia[J]. Acupuncture research, 1999, (3): 192-197.
将 68只 SD大鼠双侧颈总动脉切断造成急性不完全性脑缺血的实验性血管性痴呆(VD)模型,随机分为模型组(34只)、电针组(34只),与假术组作对照(35只)。分别检测三组的自发运动量、避暗学习反应能力、超氧化物歧化酶(SOD)、皮质醇(Cortisol)以及脑皮质、纹状体、海马、下丘脑的去甲肾上腺素( NE)、多巴胺( DA)、 5-羟色胺( 5-HT)含量。结果发现,模型组、电针组的自发运动量、避暗学习反应能力、SOD指标降低( P< 0. 001),而电针组高于模型组( P< 0. 05~0.01)。实验提示,电针能提高实验性VD大鼠的自发运动量和避暗学习反应能力,与改善脑循环,提高SOD、Cortisol、NE、DA、5-HT的活性密切相关。
68 Sprague-Dawley rats were prepared to acute
incomplete cerebral ischemia by cutting off bilateral carotid arteries
and the animal models of vascular dementia(VD) were made. Then they were divided randomly into ischemic group(Isch
34 cases)and electroacupunture group(EA
34 cases). In our study
we respectively detected the amount of autonomic activity
the response ability of learning escape dark
the contents of blood superoxide dismutase(SOD)
blood cortisol
norepinephrine(NE)
dopamine (DA)
5-hydroxytryptamine(5-HT) in cortex
striatum
hippocampus and hypathalamus. Results: the amount of autonomic activity
the response ability of learning escape dark
SOD in Isch and EA group decreased significantly (P < 0. 001) as compared with the control group (35 cases)
but those in EA group were much higher than those in Isch group (P < 0. 05-0.01 ). Conclusion: Electroacupuncture can promote the amount of autonomic activity and the response ability of learning escape dark in the animal model of VD
which closely related with improving the cerebral circulation
enhancing the ability of SOD
cortisol
NE
DA and 5-HT.
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