尾核中NMDA和非NMDA受体参与皮层SmI对丘脑束旁核伤害性反应的下行性调节

陈正秋; 石宏; 徐维; 吴国冀

您当前的位置：

首页 >

文章列表页 >

尾核中NMDA和非NMDA受体参与皮层SmI对丘脑束旁核伤害性反应的下行性调节

更新时间：2023-08-11

- 尾核中NMDA和非NMDA受体参与皮层SmI对丘脑束旁核伤害性反应的下行性调节
- Participation of NMDA and Non-NMDA Receptors in Caudate Nucleus in SmI Emanating Descending Modulation of Nociceptive Responses in Parafascicular Nucleus
- 针刺研究 1999年第3期页码：165-168
- 作者机构：
  
  中国中医研究院针灸研究所,北京,100700
- 作者简介：
- 基金信息：
  
  国家自然科学基金!（No．39670897）
- DOI：
  中图分类号：
- 纸质出版日期：1999
- 稿件说明：
移动端阅览
陈正秋, 石宏, 徐维, 等. 尾核中NMDA和非NMDA受体参与皮层SmI对丘脑束旁核伤害性反应的下行性调节[J]. 针刺研究, 1999,(3):165-168.

Participation of NMDA and Non-NMDA Receptors in Caudate Nucleus in SmI Emanating Descending Modulation of Nociceptive Responses in Parafascicular Nucleus[J]. Acupuncture research, 1999, (3): 165-168.
陈正秋, 石宏, 徐维, 等. 尾核中NMDA和非NMDA受体参与皮层SmI对丘脑束旁核伤害性反应的下行性调节[J]. 针刺研究, 1999,(3):165-168. DOI：

Participation of NMDA and Non-NMDA Receptors in Caudate Nucleus in SmI Emanating Descending Modulation of Nociceptive Responses in Parafascicular Nucleus[J]. Acupuncture research, 1999, (3): 165-168. DOI：

摘要

本文探讨尾核中ＮＭＤＡ和非ＮＭＤＡ受体是否参与皮层体感运动Ｉ区（ＳｍＩ）对丘脑束旁核（Ｐｆ）伤害性反应和针刺镇痛的下行性调节。结果发现，双侧尾核头部分别微量注射ＮＭＤＡ受体的拮抗剂Ｄ－ＡＰ５（ｎ＝１１）和非ＮＭＤＡ受体拮抗剂ＤＮＱＸ（ｎ＝９）后谷氨酸兴奋皮层ＳｍＩ对Ｐｆ神经元伤害性反应的抑制效应均被明显减弱，与盐水对照组（ｎ＝１３）的抑制效应相比，均有显著差别（ＡＮＯＶＡ，Ｐ＜０．０５）。尾核内微量注射ＤＮＱＸ后，电针（ｎ＝１１）抑制Ｐｆ神经元伤害性反应的效应显著减弱，与盐水对照组相比，差别显著（ＡＮＯＶＡ，Ｐ＜０．０５）。提示尾核中ＮＭＤＡ和非ＮＭＤＡ受体均参与兴奋皮层ＳｍＩ对Ｐｆ神经元伤害性反应的下行调节，而非ＮＭＤＡ受体还参与电针对Ｐｆ神经元伤害性反应的抑制作用。

Abstract

The present study aimed to investigate whether NMDA and non-NMDA receptors in the caudate nucleus (Cd) were involved in SmI originating descending modulation on neurons in parafascicular nucleus (Pf) in acupuncture analgesia. It was found that after bilateral microinjection of D-AP5 and DNQX

the antagonist of NMDA and non-NMDA receptors respectively

into the head of Cd the inhibitory effect of conical excitation induced by glutamate application at SmI was obviously diminished

compared with that in the saline control group (ANOVA

P < 0. 05 ). In addition

the inhibitory effect of electro-acupuncture (EA) on nociceptive responses of neurons in Pf was also significantly attenuated by microinjection of DNQX

but not by that of D-APS. The attenuation was also significant statistically (ANOVA

P < 0. 05 ). It is indicated that both NMDA and non-NMDA receptors in Cd are involved in SmI originating descending modulation on nociceptive responses of neurons in Pf. Besides

non-NMDA receptors also participate in EA-induced inhibition on nociceptive responses of neurons in Pf.

关键词

Keywords

references

浏览量

下载量

CNKI被引量

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据