阿片肽对生长抑素镇痛和加强电针镇痛作用的影响

刘玲爱; 胡蓉; 王静明; 余静; 宋朝佑; 林葆城

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阿片肽对生长抑素镇痛和加强电针镇痛作用的影响

更新时间：2023-08-11

- 阿片肽对生长抑素镇痛和加强电针镇痛作用的影响
- The Effect of Opiate Peptides on Somatostatin-induced Analgesia and Enhancing Electroacupuncture Analgesia
- 针刺研究 1999年第3期页码：172-178
- 作者机构：
  
  解放军北京医学高等专科学校生理学教研室,北京,100071
- 作者简介：
- 基金信息：
- DOI：
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- 纸质出版日期：1999
- 稿件说明：
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刘玲爱, 胡蓉, 王静明, 等. 阿片肽对生长抑素镇痛和加强电针镇痛作用的影响[J]. 针刺研究, 1999,(3):172-178.

The Effect of Opiate Peptides on Somatostatin-induced Analgesia and Enhancing Electroacupuncture Analgesia[J]. Acupuncture research, 1999, (3): 172-178.
刘玲爱, 胡蓉, 王静明, 等. 阿片肽对生长抑素镇痛和加强电针镇痛作用的影响[J]. 针刺研究, 1999,(3):172-178. DOI：

The Effect of Opiate Peptides on Somatostatin-induced Analgesia and Enhancing Electroacupuncture Analgesia[J]. Acupuncture research, 1999, (3): 172-178. DOI：

摘要

本工作以钾离子透入引起大鼠甩尾为痛指标，观察了内源性阿片肽与ＳＳ镇痛及加强电针镇痛作用的关系。侧脑室注射纳洛酮可部分阻断ＳＳ的镇痛和增强电针镇痛的效应，说明ＳＳ的镇痛和增强电针镇痛的作用可能与内源性阿片肽有关。侧脑室分别给予抗β－内啡肽血清（ＡＥＰＳ）、抗亮－脑啡肽血清（ＡＬＥＫＳ）和抗强啡肽血清（ＡＤＹＮＳ），观察到ＡＥＰＳ和ＡＬＥＫＳ可减弱ＳＳ的镇痛和增强电针镇痛的效应，其中ＡＥＰＳ减弱ＳＳ的镇痛作用较强，ＡＬＥＫＳ减弱ＳＳ增强电针镇痛的作用较强，而ＡＤＹＮＳ无论对ＳＳ的镇痛作用还是增强电针镇痛的作用均无影响。以上结果表明ＳＳ的镇痛和增强电针镇痛的作用与β－内啡肽和脑啡肽有关，而与强啡肽关系不大。

Abstract

It was observed the effects of intracerebroventricular (i. c. v. ) injection of naloxone and anti- opi- oid peptide sera on the analgesia and the enhancement of electroacupuncture (EA ) analgesia caused by somatostatin (SS) in this study. Injection(i. c. v. ) of naloxone could block partly the analgesia and the enhancement of electroacupuncture(EA) analgesia caused by SS

which suggested that analgesia and the enhancement of EA analgesia caused by SS might be related to endogenous opiate peptides (EOP). After injection (i. c. v. ) of anti-beta-endorphin serum(AEPS)

anti-fen-enkephalin serum(ALEKS)

anti-dynorphin A1-13 serum(ADYNS) respectively

it was found that AEPS and ALEKS could reduce the effect of SS on analgesia and EA analgesia

but ADYNS failed to have any effect. AEPS could stronger reduce the effect of SS on analgesia but ALEKS has a stronger action to reduce the effect of SS on EA analgesia. Those results implied that the role of SS in analgesia and enhancing EA analgesia was related with beta-endorphin and enkephalin

but not dynorphin in the central nervous system.

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