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1. 上海市针灸经络研究所,上海,200030
2. 上海长征医院,上海,200003
纸质出版日期:1999
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吴焕淦 , 潭卫林 , 陈汉平 , 等. 艾灸治疗溃疡性结肠炎疗效及对肠上皮细胞HLA-DR抗原的影响[J]. 针刺研究, 1999,(1):12-16.
Effect of Moxibustion on Ulcerative Colitis and Expression of HLA-DR Antigen on Epithelial Cell of the Colon[J]. Acupuncture research, 1999, (1): 12-16.
临床研究共收治慢性溃疡性结肠炎 151例,随机分成隔药灸 Ⅰ组(65例)、隔药灸Ⅱ组(56例)和对照组(30例),其中隔药灸 Ⅰ组,近期痊愈率达 53.8%,总有效率为 92.3%;隔药灸 Ⅱ组,近期痊愈50.0%,总有效率为89.3%;对照组,近期痊愈率30.0%,总有效率为66.7%。其作用机理可能是通过抑制和/或消除肠上皮细胞HLA-DR抗原的表达,增加(强)T_8
+
细胞数与功能,调整T淋巴细胞亚群间的比例关系而使结肠粘膜病变得以有效地纠正。151 patients with ulcerative colitis were divided randomly into herbal cake-separated moxibustion group Ⅰ (65 cases)
herbal cake-separated moxibustion group Ⅱ (56 cases)and drug group (30 cases)as a control. A good clinical result was obtained. The short-term curative rate was 53. 8 per cent in herbal cake-separated moxibustion group Ⅰ
50. 0 per cent in herbal cake-separated moxibustion group Ⅱ and 30. 0 per cent in drug group. The effective mechanism of treatment may be relevant to depressing or eliminating the antigenic expression of HLA-DR in colonic epithelial cell
increasing the amount of T_8+细胞数与功能,调整T淋巴细胞亚群间的比例关系而使结肠粘膜病变得以有效地纠正。
151 patients with ulcerative colitis were divided randomly into herbal cake-separated moxibustion group Ⅰ (65 cases)
herbal cake-separated moxibustion group Ⅱ (56 cases)and drug group (30 cases)as a control. A good clinical result was obtained. The short-term curative rate was 53. 8 per cent in herbal cake-separated moxibustion group Ⅰ
50. 0 per cent in herbal cake-separated moxibustion group Ⅱ and 30. 0 per cent in drug group. The effective mechanism of treatment may be relevant to depressing or eliminating the antigenic expression of HLA-DR in colonic epithelial cell
increasing the amount of T_8
+
cells
correcting the proportion of the subgroups of T lymphocyte
and resulting in the improvement of the injured intestinal mucosa.
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