In the present study

the effect of pricking blood of "twelve-well points of the hand" in resisting cerebral ischemia was observed in 31 rabbits. These rabbits were randomly divided into control group (n = 10 )

ischemia group (n = 11 ) and ischemia plus blood letting group (n = 10). Results showed that two hours after occlusion of rabbit bilateral common carotid arteries

contents of Ca

(2+)

lipid peroxide (LPO) and cAMP of the brain tissues all increased significantly (P

<

0. 05)

but the activity of both superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) lowered evidently (P

<

0. 01

0. 05)

indicating overload of intracellular Ca(2+)

lipid peroxide (LPO) and cAMP of the brain tissues all increased significantly (P

<

0. 05)

but the activity of both superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) lowered evidently (P

<

0. 01

0. 05)

indicating overload of intracellular Ca

(2+)

and increase of oxygen free radical. After bloodletting of "twelve-well points"

contents of Ca(2+) and increase of oxygen free radical. After bloodletting of "twelve-well points"

contents of Ca

(2+)

malonyldialdehyde (MDA) and cAMP lowered sig- nificantly (P

<

0. 05 )

while the activity of SOD increased considerably (P

<

0. 01 ). Results suggested that blood-letting of "twelve-well points" could resist cerebral ischemia-induced overload of intracellular Ca(2+)

malonyldialdehyde (MDA) and cAMP lowered sig- nificantly (P

<

0. 05 )

while the activity of SOD increased considerably (P

<

0. 01 ). Results suggested that blood-letting of "twelve-well points" could resist cerebral ischemia-induced overload of intracellular Ca

(2+)

of the brain tissues and prevented the toxic action of oxygen free radical.