Objective: To observe the effect of granule moxibustion on saliva amylase activity and the Serum SIgA. Methods: One hundred and twelve diarrhea patients were randomly divided into treatment group (n= 56) and control group (n= 56). Patients of treatment group were treated by granule moxibustion over Pishu (BL 20)

Weishu (BL 21) and Zusanli (ST 36)

once every other day

three cones per point

continuously for 30 days. Fifty six cases in control group were treated with Chinese herbal medicine (Shenling Baizhu Powder Powder of Ginseng

Poria and Bighead Atractylodes

6 g/time

3 times/day

continuously for one month). Results: Granule moxibustion could obviously improve the clinical symptoms (P<0.05～P～0.001) and increase saliva amylase activity (P<0.001)

while decrease Serum SIgA (P<0.05). The therapeutic effect of acupuncture was superior to that of Chinese herbal medicine (P<0.01

P<0.05). Conclusion: Granule moxibustion over Pishu (BL 20) etc has a definite beneficial action on spleen deficiency type diarrhea.