本文对胰岛素抵抗 (insulinresistance

IR)的机理研究进展作一简单概述

据此阐明针刺具有改善胰岛素抵抗的作用

并就针刺干预胰岛素抵抗的可能作用靶点提出构想

认为在受体前、受体及受体后水平来研究针刺改善胰岛素抵抗

最有可能揭示其作用机理

为进一步研究针刺改善胰岛素抵抗提供思路In the present study

the authors review some advances of the research on insulin resistance (IR) and the possible action target sites of acupuncture in relieving IR related diabetes

hypertension

adiposis

etc. Findings show that pre receptor and post receptor factors may be responsible for the occurrence of IR. Pre receptor factors generally include ① Insulin (Ins) gene mutation; ② formation of endogenous and exogenous Ins antigens

③ Ins receptor antigen formation

④ acceleration of Ins degradation

and ⑤ excessive Ins resisting hormones including glucocorticoid hormone

catecholamine

glucagon

free fatty acid

etc. The post receptor factors mainly contain ① receptor biosynthesis rate lowering induced reduction of receptor count

② abnormal process of receptor inserting into cellular membrane

③ reduction of receptor affinity with Ins

④ acceleration of receptor degradation

and disturbance of receptor re utilization. The possible acupuncture target sites for bettering IR are ① lowering serum Ins level

② raising C peptide/Ins

③ increasing Ins resisting hormone content

and ④ elevating Ins sensitivity. The authors also put forward some suggestions about the research on mechanisms of acupuncture in relieving IR from pre receptor

receptor and post receptor levels.