本文观察电针“足三里”穴对吗啡戒断大鼠β EP免疫调节作用的影响

探讨针刺祛毒扶正的作用机理。结果表明

电针组血清和垂体内 β EP含量增加

IL 1、IL 2升高

免疫器官重量和体重比吗啡对照组明显增加

垂体β EP与IL 1之间呈正相关趋势。提示针刺脱毒扶正

改善戒断症状的作用可能与β EP对细胞因子的良性调节有关Objective: To observe the effect of electroacupuncture (EA) of"Zusanli"(ST 36) on the immunoregulating action of β EP in rats with morphine abstinence syndrome for studying the mechanism of acupuncture in dispelling toxin and reinforcing body resistance. Methods: A total of 24 rats were divided into control group (n=8)

morphine group (n=8) and EA group (n=8). Rat morphine abstinence syndrome model was made by intramuscular injection of morphine (20 mg/kg for the first day

double

3 times and 4 times for the following 3 days

and 100 mg/kg for the 5th ～8th day). EA (2 Hz ～100 Hz

10 V

continuous waves) was applied to "Zusanli" (ST 36)

once daily and continuously for 8 days. Serum IL 1

IL 2

β EP contents and β EP level of hypophysis were detected using radioimmunoassay.Results: The results showed that in comparison with morphine group

the rat body weight

spleen weight and thymus gland weight

β EP in serum and hypophysis

Serum IL 1 and IL 2 of EA group and normal group increased significantly (P<0.05 ～0.001). There was a positive correlation between β EP of hypophysis and IL 1 in EA group. Conclusion: Results suggest that the effect of acupuncture in improving symptoms of abstinence symposium might be related to favorable regulation of β EP on cellular factors.