Acute model of gastric mucosal damage induced by perfusion of the 70% ethanol in to stomachwas estab1ished. Gastric mucosal blood flow(GMBF)

transmucosal potential difference(PD) and gastric mucosal lesion indices and the contents of nitric oxide (NO) in blood and gastric mucosal were detected. The protective effect of moxibustion(M) on gastric mucosal damage in rats and the relationwith nitric oxide were studied. The results obtained were as follows: 1) M has protective effect on gastric mucosal damage in rats. 2) Both precursor of NO-L-arginine(L-arg) and donor of NO-natrii nitroprussidum(SNP) also has the protective effect on gastric mucosal damage in rats. But NO synthesis inhibltor-NG-nitric-L-arginine(L-NNA) could not have the gastroprotective effect. 3 ) By both pretreatment of L-arg and SNP

the gastroprotective effect of M was increased

but by pretreatment of L-NNAand L-arg

the gastroprotective effect was reversed. However

by pretreatment of I

-NNA

the gastroprotective effect of M was decreased. Conclusion: the protective effect of M on gastric mucosal damagein rats was mediated through activation of L-arg-NO pathway