many hypothesizes about the mechanism of acupuncture therapy have been proposed by international scholars with different backgrounds. The present paper based on the knowledge of cytobiology and physiology mainly focuses on the relationship between acupuncture induced Deqi (achieving needling sensations) phenomenon and connective tissues. Also
it reviews the researches about the signaling transduction between cells and extracellular matrix (ECM) in the connective tissue. By doing so
we attempt to explain the relevance of the connective tissue to acupuncture and its effectiveness.