目的 :探讨电针“中膂俞”对L 多巴诱发膀胱活动亢进的尿动力学影响。方法 :以L 多巴诱发的膀胱活动亢进为动物模型

在动物清醒和自由活动的状态下

应用连续膀胱测压技术动态观察电针“中膂俞”对排尿过程中尿动力学参数的影响。结果 :电针“中膂俞”可减少排尿频率

降低膀胱基础压

升高膀胱最大充盈压和排尿压

增加排尿量。结论 :电针“中膂俞”对L 多巴诱发的膀胱活动亢进具有良好的抑制作用Objective: To observe the effects of electroacupuncture (EA) of "Zhonglushu" (BL 29) on urodynamics in L-dopa induced bladder hyperactivity. Methods: 72 SD rats were randomly and evenly divided into normal group

model group and EA group. Overactivity model of the bladder was established by intraperitoneal injection of 5% benserazid (2.5 mL/kg) and 1% L-dopa(2.5 mL/kg). Before each experiment

a median incision of the bladder was performed for intubation to measure various parameters of urodynamics. 3 days later

continuous cystometrogram was recorded under conscious state and without any restraint for observing the effects of EA on L-dopa-induced bladder overactivity. For animals of normal control group

normal saline (2.5 mL/kg) was injected intraperitoneally

and those of model and EA groups were injected with benserazid and L-dopa. Bilateral "Zhonglushu" (BL 29) were punctured and stimulated with an EA therapeutic apparatus (5 Hz

4～6 V and 30 min). Results: Before treatment

the basic pressure (Pbas)

maximal filling pressure (Pmax)

micturition pressure (Pm)

micturition circle (MC)

time of micturition (Tm)

number of micturition (Nm) and volume of micturition (Vm) had no apparent differences among the 3 groups (P>0.05). Half an hour and an hour after treatment

compared with normal control group

Nm and Pbas of model and EA groups increased significantly (P<0.05)

while Pmax

Pm and Vm of the latter two groups decreased considerably (P<0.05). In comparison with model group

one hour after treatment

Nm and Pbas of EA group were markedly lower

whereas Pmax

Pm and Vm were strikingly higher (P< 0.05). It indicates that EA can lessen micturion frequency and bladder basal pressure

and increase micturition pressure and micturition volume in bladder hyperactivity rats. Conclusion: EA of "Zhonglushu" can inhibit the hyperactivity of the bladder effectively.