为了解针刺调节脑缺血再灌注后细胞凋亡基因表达的研究进展情况

本文对近几年的有关文献进行了归纳总结

发现针刺对脑缺血再灌注损伤后多种细胞凋亡基因的表达均有调节作用

总的说来

针刺可抑制促细胞凋亡基因的表达

而促进抑细胞凋亡基因的表达。本文还对其机制进行了探讨In the present paper

the authors review recent advan ce s of acupuncture modulation on the expression of apoptosis-related genes in the brain tissues following local cerebral ischemia-reperfusion. Experimental find ings show that: electroacupuncture can 1) up-regulate expression of heat shock protein (HSP

functioning in promoting synthesis of new ribosome and restoratio n of cellular nucleus structure

protecting mitochondria and suppressing apoptos is) and potentiate the transcription of HSP 70 mRNA in the ischemic cerebral tis su es in the rat; 2) suppress or up-regulate expression of c-fos (immediate early gene) protein and c-fos mRNA of hippocampus

cerebral frontal lobe

etc.; 3) u p -regulate expression of Bcl-2 gene (serving to suppress apopotosis) and nerve growth factor (NGF) mRNA and down-regulate expression of Bax (a gene for ant agon izing Bcl-2) and P53 gene (accelerating apoptosis) of the ischemic area; 4) red uce IL-1 mRNA expression of the striate body

and suppress ischemia-induced ri se of blood TNF-α level; and 5) lower cerebral contents of excitatory amino ac ids

inhibit formation of free radicals

and reduce overload of intracellular Ca 2+ . The effects of acupuncture mentioned above may contribute to its bene ficial action in the treatment of cerebral inf arction patients in clinic.