In the present paper

the authors review recent pr ogresses of acu-moxibustion tr eatment of experimental diabetes mellitus(DM)and insulin resistance(IR)of ty pe Ⅱ(TⅡ)DM and other endocrinous metabolism-associated diseases (EMAD )from 1) study on the effect of acu-moxibustion on experimental DM and its chronic comp li cations(diabetic vascular pathological change

nervous lesion and retinopathy) and mechanisms

and 2) study on the effect of acu-moxibustion on insulin growth fact or-1 receptor (IGF-1R) in TⅡDM and EMAD animals. In addition

the authors p ut f orward some existent problems in the research on DM

IR and EMAD

such as ① the generally acknowledged effective acupoints; acupuncture induced effect or stres s reaction

② needling maneuvers

needle retention duration and stimulation int ensities

③ systematic study on the effect of the metabolism of glucose and fa t

glycosylation-oxydation stress

aldose-reductase activity on the occurrenc e a nd development of the complications of DM

the interaction among hormones

and i ts relation to nerve-endocrine-immune network

④ different levels of resea rche s including wholism

cytology and molecular biology

⑤ the acting target site o f acupuncture

⑥ indexes and evaluating methods for IR

⑦ the effect of fre e fatty acid on IR

and ⑧ new trains of thought for improving IR.