Objective:To explore actions of acupoint injection of Camphol on the permeability of blood-brain barrier and the relevant mechanisms.Methods:30 SD rats were randomly divided into acupoint injection group 1(low dosage

AI-1 group)

acupoint injection group 2(high dosage

AI-2 group)

electroacupuncture (EA) group."Yamen"(GV 15) was used for injection of Camphol(0.4 g/kg and 0.8 g/kg)

and "Baihui" (GV 20) was used for EA stimulation (50 Hz

5 mA

for 15 min

once again 5 hr later). After treatment

the rats were killed for taking brain tissues that were then processed into supernate for detecting the permeability of blood-brain barrier of rats with spectrophotometric analysis. Results:After treatment

groups can promote the permeability of blood-brain barrier in rats

but the contents of Even's Blue in the brain tissues in the 3 treatment groups all significantly higher than that of control group (P<0.05～0.001)

suggesting that acupoint injection and EA can strengthen the permeability of blood-brain barrier to Even's Blue. Comparison among the 3 treatment groups showed that the contents of Even's Blue of AI-1 and AI-2 groups were markedly higher than that of control group (P<0.05). Conclusion:Acupoint injection of Camphol can effectively improve the permeability of blood-brain barrier

which is better than that of electroacupuncture.