Objective:To observe the effect of electroacupuncture (EA) of “Zusanli(ST 36) on expression of Bcl 2 and Fas proteins in alcohol induced gastromucosal lesion rats for analyzing the relationship between cytoprotection and expression of Bcl 2 and Fas proteins

and the point relative specificity.Methods:40 Wistar rats were randomly and evenly divided into “Zusanli"(ST 36)

non acupoint

model and control groups. Gastric mucosal injury model was induced by intragastric infusion of dehydrated alcohol (1 mL per animal). The expression of Bcl 2 and Fas proteins in each group were detected with immunohistochemical techniques.: Expression of Bcl 2 protein of gastric mucosa tissues in “Zusanli" group was obviously stronger than that of model group( P <0 05 ).Expression of Fas protein in “Zusanli" group was decreased significantly in comparison with model and non acupoint groups ( P <0 01)

suggesting that acupuncture of “Zusanli" generated up regulation of Bcl 2 expression and down regulation of Fas expression may contribute to its effect in protecting the gastromocosal tissue from injury and the effect of acupuncture of “Zusanli" is of relative specificity.:Electroacupuncture of “Zusanli"(ST 36) can up regulate expression of Bcl 2 and down regulate expression of Fas protein of gastromucosal tissues and the effect of “Zusanli"(ST 36) possesses a relative specificity.