Objective: To observe the effect of electroacupuncture(EA) combined with Clomipramine(Clo) on behavioral activities of depression rats.Methods: Forty-eight SD rats were randomized into normal control

model

EA

Clo(2.5 mg)

Clo(5 mg) and EA+Clo(2.5 mg) groups

with 8 cases in each group.Chronic unpredictable stress(CUS) model was established by forcing the rat to have fasting

cool-water swim

water-deprivation

high temperature environment

etc.in 28 days.EA((4 Hz) and (60 Hz)

duration of the pulse train:(2.5 s) and(5 s)

≤(1 mA)) was applied to "Baihui"(GV 20) and right "Yanglingquan"(GB 34) for(30 min)

once every other day

7 times altogether.CHP was given to the animals by intraperitoneal injection.The open-field test was used to observe the rats' rearing and crossing activities

and the forced swim test was employed to determine the rats' duration of immovability(DI) during(5 min) in a water pool.Results: In comparison with normal control group

the rearing and crossing movement times of rats in model group decreased significantly(P

<

0.05);while compared with model group

the rearing times of rats in EA

Clo(2.5 mg)

Clo(5 mg) and EA+Clo(2.5 mg) groups

and crossing movement times of rats in EA

Clo(5 mg) and EA+Clo(2.5 mg) groups increased remarkably(P

<

0.05)

and the effect of EA+Clo(2.5 mg) was significantly superior to those of EA and Clo(2.5 mg) groups in the rearing times and to that of EA group in the crossing times(P

<

0.05).In comparison with normal control group

the rats' DI in the water pool in model group prolonged significantly(P

<

0.05);while compared with model group

the DI of EA

Clo(5 mg) and EA+Clo(2.5 mg) shortened significantly(P

<

0.05)

and the effect of EA+Clo(2.5 mg) group was significantly superior to that of EA group on the 28

(th)

day(P

<

0.05).Conclusion: EA works well in relieving