电针对抑郁模型大鼠行为学的影响

韩焱晶; 贾宝辉; 时宇静; 图娅

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电针对抑郁模型大鼠行为学的影响

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- 电针对抑郁模型大鼠行为学的影响
- Effect of Electroacupuncture on Changes of Behavior in Depression Rats
- 针刺研究 2005年第3期页码：146-149
- 作者机构：
  
  1. 中国中医研究院针灸研究所
  2. 北京中医药大学针灸学院
  3. 北京中医药大学针灸学院,北京,100700
- 作者简介：
- 基金信息：
  
  国家教委博士点课题(No.20030026005)
- DOI：
  中图分类号：
- 纸质出版日期：2005
- 稿件说明：
移动端阅览
韩焱晶, 贾宝辉, 时宇静, 等. 电针对抑郁模型大鼠行为学的影响[J]. 针刺研究, 2005,(3):146-149.

Effect of Electroacupuncture on Changes of Behavior in Depression Rats[J]. Acupuncture research, 2005, (3): 146-149.
韩焱晶, 贾宝辉, 时宇静, 等. 电针对抑郁模型大鼠行为学的影响[J]. 针刺研究, 2005,(3):146-149. DOI：

Effect of Electroacupuncture on Changes of Behavior in Depression Rats[J]. Acupuncture research, 2005, (3): 146-149. DOI：

摘要

目的:通过观察电针对抑郁模型大鼠行为的影响

明确针刺治疗抑郁症的作用

并为进一步的机制研究提供依据。方法:30只SD大鼠随机分为正常组、模型组和电针组

每组10只。用慢性不可预见性轻度刺激结合孤养的方法造模

给予模型组和电针组21 d不同的应激刺激。造模同时针刺治疗电针组动物

选取“百会”“印堂”穴

频率2 Hz

电流强度为0.6 mA左右

留针20 min

每日1次

连续针刺21 d。于实验前1 d、实验第7、142、1 d测量大鼠体重

并进行开野实验及糖水消耗试验。结果:造模7 d后模型组的体重、水平运动和垂直运动即明显低于正常组(P<0.05

0.01

0.001);电针组的体重在第7 d也出现了减少(P<0.001)

与模型组一直未见差异

但水平运动与垂直运动次数始终高于模型组(P<0.05

0.01

0.001)

与正常组未见差异。第21 d的糖水消耗试验显示

模型组相对糖水消耗量低于正常组和电针组(P<0.05)

电针组与正常组之间无显著差异。结论:慢性不可预见性轻度刺激结合孤养的方式能造成大鼠中枢奖赏系统的功能低下

电针能够防治由此引发的大鼠行为学的改变。

Abstract

Objective: To observe the effect of electroacupuncture(EA) on changes of behavior in depression rats.Methods: Thirty male SD rats were evenly randomized into control

model and EA groups.Depression model was established by using chronic unpredictable mild stress(CUMS) stimulation(forced ice-water swimming

electric shock

tail-clamping

etc) combined with lonely raising for 21 days.EA(2 Hz

(0.6 mA

) 20 min) was applied to "Baihui"(GV 20) and "Yintang"(EX-HN 3)

once daily

continuously for 21 days.The rat's body weight

open-field test

absolute and relative volume of sucrose-intake were recorded one day before experiments

and on the 7

(th)

14(th)

(th)

and 21(th) and 21

(st)

day during experiments respectively.Results: Compared with control group

the rats' body weight

crossing and rearing motion times and sucrose-intake volume decreased significantly in model group(P

0.05

0.01

0.001).From the 7(st) day during experiments respectively.Results: Compared with control group

the rats' body weight

crossing and rearing motion times and sucrose-intake volume decreased significantly in model group(P

0.05

0.01

0.001).From the 7

(th)

to 21(th) to 21

(st)

day

the body weight of both model and EA groups was significantly lower than that of control group(P

0.001)

but no significant difference was found between model and EA groups.Compared with control group

the crossing and rearing movement times on the 7(st) day

the body weight of both model and EA groups was significantly lower than that of control group(P

0.001)

but no significant difference was found between model and EA groups.Compared with control group

the crossing and rearing movement times on the 7

(th)

and 21(th) and 21

(st)

day

the absolute volume of sucrose-intake on the 14(st) day

the absolute volume of sucrose-intake on the 14

(th)

and 21(th) and 21

(st)

day

and the relative volume of sucrose-intake on the 21(st) day

and the relative volume of sucrose-intake on the 21

(st)

day of model group decreased significantly(P

0.05

0.01

(0.001).) In comparison with model group

the rats' crossing and rearing movement times from 7(st) day of model group decreased significantly(P

0.05

0.01

(0.001).) In comparison with model group

the rats' crossing and rearing movement times from 7

(th)

to 21(th) to 21

(st)

day

absolute and relative volume of sucrose-intake on the 21(st) day

absolute and relative volume of sucrose-intake on the 21

(st)

day increased considerably in EA group(P

0.05

0.01

0.001).The results suggested that EA could prevent or suppress the onset of depression and raise the volume of sucrose-intake in depression rats.Conclusion: CUMS combined with lonely breeding may cause a hypofunction of the rat's central reward system

whereas EA treatment can prevent the rat's abnormal behavior.

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