目的:探讨穴位敷贴治疗哮喘的机理。方法:将40只豚鼠随机分为正常对照组、哮喘模型组、穴位敷贴组、地塞米松组

每组10只。处理结束后采用酶联免疫吸附测定法检测血清E、P选择素水平。结果:模型组豚鼠血清E、P选择素水平明显高于正常对照组(P<0.01)

穴位敷贴组和地塞米松组血清E、P选择素水平明显低于模型组(P<0.01)。结论:穴位敷贴可明显降低哮喘豚鼠血清E、P选择素的水平

这可能是其治疗哮喘的作用机理之一。Objective:To investigate the underlying mechanism of acupoint application in the treatment of asthma.Methods: Forty Hartly guinea-pigs were randomized into control

model

acupoint application and dexamethasone(DEX) groups.Asthma model was established by intraperitoneal injection of 10% egg albumin and 1% egg albumin aerosol inhaling method.Herbal cake made up of Mahuang(麻黄Herba Ephedrae)

Xixin(细辛Herba Asari)

Gansui(甘遂Radix Euphorbiae Kansui)

etc was applied to "Dazhui"(GV 14)

"Feishu"(BL 13) and "Shenshu"(BL 23)

6 h every time

once every other day

7 days altogether.For rats of DEX group

DEX(0.5 mg/kg) was injected intraperitoneally.Blood samples were collected for detecting E-selectin and P-selectin contents by using enzyme-linked immunosorbent assay.Results: The levels of serum E-selectin and P-selectin of model group were significantly higher than those of normal control group(P<0.01).Compared with model group

the levels of serum E-selectin and P-selectin of acupoint application group and DEX group were significantly lower(P