电针“大椎”“命门”对佐剂性关节炎大鼠应激相关因子影响的实验研究

李辉; 李晓泓; 张露芬; 曲黎敏

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电针“大椎”“命门”对佐剂性关节炎大鼠应激相关因子影响的实验研究

更新时间：2023-08-11

- 电针“大椎”“命门”对佐剂性关节炎大鼠应激相关因子影响的实验研究
- Influence of Electroacupuncture of "Dazhui"(GV14) and "Mingmen"(GV4) on Stress-related Factors in Adjuvant Arthritis Rats
- 针刺研究 2006年第1期页码：8-11
- 作者机构：
  
  1. 中日友好医院针灸科
  2. 北京中医药大学针灸学院
  3. 北京中医药大学针灸学院,北京,100029
- 作者简介：
- 基金信息：
  
  国家自然科学基金课题(90209026);教育部优秀青年骨干教师科研资金资助
- DOI：
  中图分类号：
- 纸质出版日期：2006
- 稿件说明：
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李辉, 李晓泓, 张露芬, 等. 电针“大椎”“命门”对佐剂性关节炎大鼠应激相关因子影响的实验研究[J]. 针刺研究, 2006,(1):8-11.

LI Hui, LI Xiao-hong, ZHANG Lu-fen, et al. Influence of Electroacupuncture of "Dazhui"(GV14) and "Mingmen"(GV4) on Stress-related Factors in Adjuvant Arthritis Rats[J]. Acupuncture research, 2006, (1): 8-11.
李辉, 李晓泓, 张露芬, 等. 电针“大椎”“命门”对佐剂性关节炎大鼠应激相关因子影响的实验研究[J]. 针刺研究, 2006,(1):8-11. DOI：

LI Hui, LI Xiao-hong, ZHANG Lu-fen, et al. Influence of Electroacupuncture of "Dazhui"(GV14) and "Mingmen"(GV4) on Stress-related Factors in Adjuvant Arthritis Rats[J]. Acupuncture research, 2006, (1): 8-11. DOI：

摘要

目的:通过观察电针“大椎”“命门”穴后下丘脑CRH、血浆ACTH、血清Cort、TNF-α含量的关系

分析电针不同穴位对应激相关因子的影响。方法:以佐剂性关节炎大鼠(AA)作为研究对象

随机分正常组、模型组、电针“大椎”组、电针“命门”组。观察电针对关节炎症局部及下丘脑CRH、血浆ACTH、血清Cort、TNF-α含量的影响。结果:“大椎”组、“命门”组经治疗右后足足爪肿胀率与模型对照组比较极明显降低(P<0.01)

“大椎”组下丘脑CRH含量、血清Cort、TNF-α含量

“命门”组血清Cort含量与模型对照组比较明显降低(P<0.05)。结论:电针具有一定的抗炎作用

并且这种作用可能是通过对CRH、Cort等应激相关因子的调节

减轻疾病应激程度而实现的。

Abstract

Objective: To study the effect of electroacupuncture(EA) of "Dazhui"(GV 14) and "Mingmen"(GV 4) on hypothalamic corticotrophin releasing hormone(CRH)

plasma adrenocorticotropic hormone(ACTH)

serum cortisol(Cort) and tumor necrosis factor(TNF)-α contents in adjuvant arthritis rats.Methods: Thirty-six male Wistar rats were evenly randomized into normal control

model

EA-GV14 and EA-GV4 groups.Arthritis model was established by subcutaneous injection of Freund's complete adjuvant(FCA

(0.1 mL)) into the right hind-paw.EA((15 Hz)

continuous pulses

(1 mA)) was applied to "Dazhui"(GV 14) and "Mingmen"(GV 4) for(20 min)

once every other day and continuously for 8 times.After the rats were killed

hypothalamic tissue and blood sample were taken for detecting hypothalamic CRH

plasma ACTH

serum Cort and TNF-α contents with radioimmunoassay.Results: Compared with normal control group

the swelling rate of the right hindpaw(24 h) after injection of FCA and 16 days after EA increased significantly(P<0.01);while in comparison with model group

the swelling rates of EA-GV14 and EA-GV4 groups were markedly lower(P<0.01).Compared with normal control group

hypothalamic CRH

plasma ACTH

serum Cort and TNF-α contents of model group increased significantly(P<0.05);while in comparison with model group

hypothalamic CRH serum Cort and TNF-α contents in EA-GV14 group

and serum Cort level in EA-GV4 group decreased significantly(P<0.05).No significant differences were found between EA-GV14 and EA-GV4 groups(P>0.05) in these 4 indexes.Conclusion: EA has a marked anti-inflammatory effect in adjuvant arthritis rats and can relieve arthritis stress induced increase of hypothalamic CRH

plasma ACTH

serum Cort and TNF-α levels.

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