The present paper retrospects the research history of acupuncture and moxibustion in China

particularly expounds the background

definition

theoretical basis

goal

technological means and the life science value of the research on the substantial basis of acupuncture efficacy based on the researches about the mechanism of acupuncture actions in the past decades of years

and studies about serum proteome in recent years.The research on the substantial basis of acupuncture effects should take the essence of the life phenomena as the starting point of strategy

and the response genes and response proteins of acupuncture efficacy as the primary technical tactics for explaining the underlying biological mechanisms of acupuncture effects.This research project has higher theoretical altitude and clear academic innovation

and important strategic significance for maintaining the leading position in the field of acupuncture research in the world and for owning originally creative independence intellectual property rights.Moreover

this article also puts forward a few methods for the application of achievements of researches on the substantial basis of acupuncture effects.This research project may have a very active significance for unfolding the future developmental direction of acupuncture research.