The essence of meridian-collateral system is one of the momentous theoretical topics of the life science.In recent years

many authors have been trying to elucidate various kinds of meridian phenomenon from different points of view including physics

chemistry

biology

traditional Chinese medicine

modern science and so on.The physical detection results intuitively indicated biophysics specificities of meridians

including electricity

heat

sound

light

magnesium

the migration of the injected isotope along the running route of meridians and so on.Results of the studies on chemical materials(ion

PO2

neurotransmitters) within the tissues along the meridian and those of cell junction communications showed that some chemical substances have a close relation with the meridian activities.This review summarizes recent research results on meridian and acupoints from biophysics and biochemistry in order to have a comprehensive understanding in this field.