Objective:To observe the effect of electroacupuncture(EA)of "Xiusanzhen" on anti-oxidation in cerebral ischemia-reperfusion(CI-R)injury rats and to analyze its underlying mechanism in resisting cerebral ischemic injury.Methods:A total of 30 SD rats were randomized into sham

model and EA groups

with 10 cases in each.CI-R model was established by reversible occlusion of the middle cerebral artery.EA(80-100 Hz

1-3 mA)was applied to "Xiusanzhen"(the mid-point of the nasal root

2 mm bilateral to the nasal root)for 60 min.The levels of catalase(CAT)

glutathione peroxidase(GSH-Px)and total anti-oxidation capability(T-AOC)in cerebral cortex tissue were determined by using spectrophotometry and chromatometry respectively.Results:Compared with control group

the levels of CAT

GSH-Px and T-AOC in model group were markedly lower(P<0.01);while compared with model group

the levels of CAT

GSH-Px and T-AOC increased significantly in EA group(P<0.01).Conclusion:EA of "Xiusanzhen" has definite effects in raising CI-R-induced decrease of CAT

GSH-Px activity and T-AOC in the cerebral cortex

which may contribute to its effect in reducing ischemic cerebral damage.