Objective:To investigate the effect of electroacupuncture(EA)on the expression of neuropeptide Y(NPY)and calcitonin gene-related peptide(CGRP)in hippocampus tissue in cerebral hemorrhage rats so as to reveal its underlying mechanism in protecting ischemic cerebral neurons.Methods:Thirty Wistar rats were randomly divided into normal control

model and EA groups

with 10 cases in each.Cerebral hemorrhage model was duplicated by intracerebral injection of collagenase Ⅶ(0.8 μL

AP:1.0 mm

R:4.0 mm).EA(1 mA

2 Hz)was applied to "Shuigou"(GV 28)for 30 min

once again 24 h later.NPY and CGRP expression of hippocampus tissue was assayed with immunohistochemical method(SABC).Results:Compared with normal control group

OD values of hippocampal NPY immuno-reaction(IR)-positive and CGRP IR-positive neurons in model group increased obviously(P<0.01

0.05)

while compared with model group the OD value of NPY IR-positive neurons in EA group decreased significantly(P<0.01)

and the OD value of CGRP IR-positive neurons increased further considerably(P<0.01).Conclusion:EA of "Shuigou"(GV 28)can suppress cerebral ischemia-induced over expression of NPY

and potentiate the expression of CGRP IR-positive neurons in the hippocampus

balancing functional activities of NPY and CGRP to improve microcirculation in the brain tissue.