Objective To explore the relationship between energy metabolism and meridian phenomenon.Methods Ten Boer hybridism goats mitigated under chlorpromazine(0.85 mg/kg

intramuscular injection) were subjected to the present study.Changes of oxygen partial pressure(PO2) in "Ganshu"(BL 18)

"Dachangshu"(BL 25) and "Guanyuanshu"(BL 26) of Bladder Meridian and in 3 non-acupoints(3 cm apart from BL18

BL25 and BL26 separately on the unilateral side) were recorded by using a needle-type tissue oxygen tension sensor before and following local injection of EDTA-Na2(200 μL

0.05 kg/mol

for complexing Ca2+) and 0.9% saline.Results ① Compared with the corresponding non-acupoints

Ca2+ potentials in BL18

BL25 and BL26 were all significantly higher(P<0.05

0.01).② In comparison with the corresponding non-acupoints

the values of tissue PO2 of BL18 and BL26 were significantly higher(P<0.01).③ After injection of EDTA-Na2

PO2 values in both BL18

BL26

and their respective non-acupoints increased significantly in comparison with those of either injection of saline or their respective basal values(P<0.01

0.05).Compared with those of their corresponding non-acupoints PO2 values in both BL18 and BL26 increased markedly(P<0.01).Conclusion Ca2+ potential of the Bladder Meridian was significantly higher than that of non-acupoints

and after complexing Ca2+

PO2 in acupoints and non-acupoints increased markedly

suggesting that Ca2+ may play an important role in meridian signaling and production of acupuncture effect.