Objective: To observe the regulative effect of electroacupuncture(EA) of Sanyinjiao(SP 6) on genito-endocrine in patients with perimenopausal syndrome(PMS).Methods:A total of 175 PMS patients(157 cases with complete data) were randomized into EA group(n=81) and medication group(n=76) according to multi-center(3 hospitals) and single-blind control trial method.EA(2/100 Hz

8-10 mA) was applied to bilateral Sanyinjiao(SP 6) for 30 min

3 times every week

with one month being a therapeutic course

3 courses altogether.Patients in medication group were ordered to take nilestriol(2 mg

twice/month for 3 months) and medrysone(2 mg

t.i.d.for 10 days from the 3rd month on).Serum estradiol(E) 2

follicle-stimulating hormone(FSH) and luteinizing hormone(LH) were detected with a chemiluminescence immo-analysis system.Results: After EA treatment

serum FSH and LH contents decreased significantly and serum E2 increased considerably(P<0.001) compared with its basic values.Comparison between two groups showed that FSH

LH and E2 levels in EA group were significantly lower than those of medication group(P<0.05).Conclusion: EA of Sanyinjiao(SP 6) has a good regulative effect on reproductive endocrine function in PMS patients.