Objective To observe the effect of electroacupuncture(EA) of "Baihui"(GV 20) and "Dazhui"(GV 14) on the ultrastructure of cerebral cortex in rats with cerebral ischemia reperfusion(CI/R) injury.Methods Fifteen SD rats were equally randomized into sham-operation(sham)

model and EA groups.CI/R model was established by right middle cerebral artery occlusion for 1 h and reperfusion for 24 h.EA(20 Hz/80 Hz

1-3 mA) was applied to "Baihui"(GV 20) and "Dazhui"(GV 14) for 30 min.The ischemic cerebral cortex tissue was taken

fixed in 2.5% glutaral solution

embedded in araldite

cut into sections and stained for observing the ultrastructure changes of cortical pyramidal cells

astrocyte and blood brain barrier(BBB) under transmission electronic microscope.Results In sham group

the anatomical structure of the cerebral pyramidal cells was normal basically.In model group

the neuronal mitochondria and the capillary endothelium and the processes of the astrocyte got swelling

the mitochondrial cristae were broken

the capillary lumens became narrow or were blocked up.In EA group

the injury degree of the pyramidal cells

glial cells and BBB were lighter.Conclusion EA can reduce ischemic injury of the cerebral cortical neurons and blood brain barrier in rats with CI/R injury.