HUANG Wei, WU Xu-ping, DING Yun1, et al. Influence of Electroacupuncture of "Shuigou"(GV 26) on Hippocampal CGRP and NPY Contents in Cerebral Ischemia Rats[J]. Acupuncture research, 2009, 34(1): 13-15.
HUANG Wei, WU Xu-ping, DING Yun1, et al. Influence of Electroacupuncture of "Shuigou"(GV 26) on Hippocampal CGRP and NPY Contents in Cerebral Ischemia Rats[J]. Acupuncture research, 2009, 34(1): 13-15.DOI:
Objective To observe the effect of electroacupuncture(EA) on the contents of hippocampal calcitonin gene-related peptide(CGRP) and neuropeptide Y(NPY) in cerebral ischemia(CI) rats.Methods Forty SD rats were randomly divided into normal control
sham operation(sham)
model and EA groups with 10 cases in each.CI model was duplicated by middle cerebral artery occlusion.EA(2 Hz
1 mA
continuous waves) was applied to "Shuigou"(GV 26) for 30 min
once daily for 5 days.Hippocampal tissue was taken for assaying the contents of CGRP and NPY with radioimmunoassay.Results Compared with sham group and normal control group
hippocampal CGRP content in model group decreased apparently(P<0.01)
while NPY content of model group increased significantly(P<0.01).Compared with model group
hippocampal CGRP in EA group increased considerably(P<0.01) and NPY content decreased obviously(P<0.01).Conclusion Electroacupuncture of GV26 can effectively adjust hippocampal CGRP and NPY contents in CI rats
which may contribute to its effect in improving cerebral ischemia.