化瘀通络灸治疗血管性认知障碍的临床疗效观察

程红亮; 钱发才; 胡培佳; 张闻东; 殷恒斌; 耿飞

doi:10.13702/j.1000-0607.170845

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化瘀通络灸治疗血管性认知障碍的临床疗效观察

临床研究 | 更新时间：2023-08-11

- 化瘀通络灸治疗血管性认知障碍的临床疗效观察
- Treatment of Vascular Cognitive Impairment by “Huayu Tongluo” Moxibustion
- 针刺研究 2018年43卷第8期页码：526-530
- 作者机构：
  
  1. 安徽中医药大学第二附属医院
  2. 安徽中医药大学研究生院
- 作者简介：
- 基金信息：
  
  安徽省卫生厅中医药科研项目(No.2012zy 37);安徽中医药大学青年科学研究项目(No.2015qn 035);安徽省自然科学基金研究项目(No.1708085 MH 200)
- DOI：10.13702/j.1000-0607.170845
  中图分类号：
- 纸质出版日期：2018
- 稿件说明：
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程红亮, 钱发才, 胡培佳, 等. 化瘀通络灸治疗血管性认知障碍的临床疗效观察[J]. 针刺研究, 2018,43(8):526-530.

CHENG Hong-liang, QIAN Fa-cai, HU Pei-jia, et al. Treatment of Vascular Cognitive Impairment by “Huayu Tongluo” Moxibustion[J]. Acupuncture research, 2018, 43(8): 526-530.
程红亮, 钱发才, 胡培佳, 等. 化瘀通络灸治疗血管性认知障碍的临床疗效观察[J]. 针刺研究, 2018,43(8):526-530. DOI： 10.13702/j.1000-0607.170845.

CHENG Hong-liang, QIAN Fa-cai, HU Pei-jia, et al. Treatment of Vascular Cognitive Impairment by “Huayu Tongluo” Moxibustion[J]. Acupuncture research, 2018, 43(8): 526-530. DOI： 10.13702/j.1000-0607.170845.

摘要

目的:观察化瘀通络灸对血管性认知障碍(VCI)患者血清胰岛素样生长因子-1(IGF-1)的表达影响

探讨其疗效机制。方法:以随机数字表法将60例VCI患者分为化瘀通络灸组(治疗组)和盐酸多奈哌齐组(对照组)

每组30例。在常规药物治疗基础上

治疗组予每周艾灸6次

对照组予盐酸多奈哌齐口服

5mg/晚

均治疗30d。观察治疗前后中医核心症状、简易智能量表(MMSE)、日常生活能力量表(ADL)及蒙特利尔认知评估量表(MoCA)

采用ELISA法检测治疗前后血清IGF-1水平。结果:治疗组临床总有效率为90.00%(27/30)

对照组为73.33%(22/30)

治疗组优于对照组(P<0.05)。与治疗前比较

治疗后两组中医症状积分显著降低(P<0.01)

MMSE积分、ADL评分、MoCA评分显著升高(P<0.01);治疗组中医症状积分、MMSE积分及ADL评分较对照组改善明显(P<0.01)。治疗后的两组血清IGF-1水平均较治疗前显著升高(P<0.01)

且治疗组显著高于对照组(P<0.01)。结论:化瘀通络灸治疗VCI疗效显著

其机制可能与提高VCI患者血清IGF-1水平相关。

Abstract

Objective To observe the therapeutic effect of"Huayu Tongluo"(blood stasis-removing and meridian-collateraldredging)moxibustion for vascular cognitive impairment(VCI)patients and changes of insulin like growth factor-1(IGF-1)levels in serum after the treatment.Methods Sixty patients with VCI were randomly divided into medication(control)and moxibustion groups(n=30 in each group).Cotton cloth-separated moxibustion was applied to Baihui(GV 20)and Shenting(GV 24)

and conventional moxibustion applied to Dazhui(GV 14)and Yongquan(KI 1)for 30 min

once daily

6 times a week and for 30 days.Patients of the control group were treated by oral administration of Donepezil hydrochloride at the dose of 5 mg/night for 30 days.The core symptoms of traditional Chinese medicine(TCM)

mini-mental state examination(MMSE)

activity of daily living(ADL)and Montreal cognitive assessment(MoCA)scales were used to assess the therapeutic effect after the treatment.The content of serum IGF-1 was determined by ELISA.Results Of the two 30 cases in the control and moxibustion groups

9 and 17 experienced marked improvement

13 and were effective

8 and 3 ineffective

with the effective rates being 73.33% and90.00%

respectively.The effective rate in the moxibustion group was obviously higher than that in the control group(P<0.05).After the treatment

the TCM symptom scores were significantly decreased

and the MMSE

ADL and MoCA scores considerably increased in both groups compared with those of their own individual pre-treatment(P<0.01).The TCM symptom score of the moxibustion group was significantly lower

and the MMSE and ADL scores were obviously higher than those of the control group(P<0.01).The serum IGF-1 content in both groups was significantly increased after the treatment relevant to that of their own individual pre-treatment(P<0.01)

and was obviously higher in the moxibustion group than in the control group(P<0.01).No significant difference was found between the two groups in the MoCA score after the treatment(P>0.05).Conclusion "Huayu Tongluo"moxibustion has a positive effect for patients with VCI

which may be associated with its effect in up-regulating serum IGF-1 level.

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