Non-invasive transcutaneous auricular vagus nerve stimulation(ta-VNS) is established on the basis of auricular acupuncture and the principle of vagus nerve stimulation(VNS). The results of the comparative study of 4 indications of VNS show that ta-VNS achieves almost the equivalent effect as VNS. Moreover

the ta-VNS is advantageous at safety

economy and portability. Regarding the clinical prevention and treatment of polycystic ovary syndrome(PCOS)

it is still controversial for the effect of acupuncture and moxibustion therapy including auricular acupuncture. Moreover

it is the difficulty for the principle of acupoint selection and the treatment mechanism of this therapy to be in line with modern medicine. As neuroendocrine disease

PCOS and the ovary

its target organ are all associated with the vagus nerve. It is a new idea to introduce the ta-VNS in treatment of PCOS by regulating the reproductive and endocrinal disturbance of PCOS in terms of vagus nerve and improving the acupuncture and moxibustion therapy

such as the auricular acupuncture. In the paper

the potential mechanism of the ta-VNS in treatment of PCOS is presented: 1)the ta-VNS treats PCOS by improving insulin resistance; 2)the ta-VNS relieves PCOS-induced psychological disorders through the treatment of depression; 3)the ta-VNS is applicable in treatment of PCOS complications

such as hypertension and diabetes.